Eli Manning will be tested on Sunday for a neck strain that will require him to sit out the entire season, New York coach Ben McAdoo said.
Manning, the reigning NFL MVP, is expected to be sidelined for two to three weeks.
McAdoos announcement came after a game in which he did not play.
The Giants defeated the Kansas City Chiefs 31-10.
McADoo did not name the Chiefs, but said that the team has spoken to Manning and that he’s “optimistic he’ll be back to his usual form by week three.”
Manning is averaging a career-high 4,096 passing yards and 19 touchdowns this season.
He has not been sacked in a game this season and his passer rating is 91.4.
He also has completed 64.2 percent of his passes this season, which would be his best completion percentage in any season since 2011.
The 49ers’ Aaron Lynch, who leads the NFL with five interceptions, is out for the season after undergoing surgery to repair a left knee injury.
He was expected to miss four to six weeks.